Sorry, you need to enable JavaScript to visit this website.
Tarpeyo Logo

DISCOVER TARPEYO

First and only FDA-approved treatment proven to reduce the loss of kidney function in adult patients with IgA Nephropathy (IgAN)

Kidney

First and only FDA-approved treatment for IgAN proven to reduce the loss of kidney function

Significantly reduces the loss of kidney function compared to blood pressure medication alone, as measured by eGFR*

gut

Only FDA-approved treatment designed to target a source of IgAN in the gut

Designed to deliver treatment to an area of the gut thought to play a role in IgAN†

9 months

Lasting results

9-month treatment with proven results over 2 years in 2 key measures (eGFR and UPCR)‡

9-month treatment

9-month treatment

4 capsules taken once a day

Financial Support

TARPEYO Touchpoints® offers programs to help you access and afford your medication

97% of TARPEYO patients have paid less than $10 per prescription§

*At 2 years, there was -5.3 mL/min/1.73 m 2 vs -11.2 mL/min/1.73 m 2 difference in kidney function as measured by eGFR in patients who received TARPEYO + blood pressure medication vs those who received blood pressure medication alone.

†It has not been established to what extent the efficacy of TARPEYO is from local effects (in the gut) vs systemic effects (in circulation).

‡At 2 years, there was an average 34% reduction from baseline in UPCR in patients who received TARPEYO plus blood pressure medication vs. 4% in those who received blood pressure medication alone.

§All patients regardless of insurance type. This includes commercial, Medicare, Medicaid, and cash-paying patients from January 2022 through February 2024.

HOW IS TARPEYO THOUGHT TO WORK?

Human intestines
Human intestines

TARPEYO is designed to deliver treatment to an area of the gut thought to play a role in IgAN. Types of cells in the gut are responsible for the production of an antibody called IgA1, which can build up in the kidneys, causing IgAN. TARPEYO can reduce the amount of this antibody.*

*It has not been established to what extent the efficacy of TARPEYO is from local effects (in the gut) vs systemic effects (in circulation).

WHAT MAKES TARPEYO UNIQUE?

Tarpeyo pill with a line indicating where in human intestines it impacts
Tarpeyo pill with a line indicating where in human intestines it impacts

The TARPEYO capsule was designed with targeted-release technology to dissolve once 
it reaches a specific area of the gut to target the IgA1 antibodies that eventually build 
up in your kidneys.

HOW WAS TARPEYO STUDIED?

TARPEYO was studied in 364 patients over 2 years
TARPEYO was studied in 364 patients over 2 years

TARPEYO was studied in 364 patients over 2 years. For 9 months, patients were on TARPEYO plus their prescribed blood pressure medicine. Then they were followed for 15 months off treatment for an observational period. The primary objective of the 2-year study was to assess the impact of TARPEYO on eGFR, a measure of kidney function. Changes in proteinuria, as measured by change in UPCR, was another objective and measured in the study. Patients in the placebo (sugar pill) control group of the study took blood pressure medicine alone.

WHAT ARE THE STUDY RESULTS WITH TARPEYO?

TARPEYO was shown to reduce the loss of kidney function vs blood pressure medication alone

TARPEYO was shown to reduce the loss of kidney function vs blood pressure medication alone
TARPEYO was shown to reduce the loss of kidney function vs blood pressure medication alone

As kidney function worsens, the eGFR number goes down. At the end of the study, people who took TARPEYO and blood pressure medication lost less of their kidney function compared to those who only took blood pressure medicine.

*At the start of the study, the average eGFR was approximately 58 mL/min/1.73 m2, with 60% of patients having an eGFR <60 mL/min/1.73 m2. 
†At 2 years, there was >50% difference in kidney function as measured by eGFR in patients who received TARPEYO + blood pressure medication vs those who received blood pressure medication alone. Calculated as relative reduction (9.4% TARPEYO + blood pressure medicine vs 20.3% blood pressure medicine alone).

TARPEYO was shown to reduce urine protein levels vs blood pressure medication alone

TARPEYO was shown to reduce urine protein levels vs blood pressure medication alone
TARPEYO was shown to reduce urine protein levels vs blood pressure medication alone

*Taken with blood pressure medicine. 
†Average UPCR percentage reduction during follow-up (over 12 to 24 months) based on longitudinal repeated measures model.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF TARPEYO?

The most common side effects of TARPEYO include:

  • swelling of the lower legs, ankles, and feet
  • high blood pressure
  • muscle spasms
  • acne
  • headache
  • upper respiratory tract infection
  • swelling of the face
  • weight increase
  • indigestion
  • irritation or inflammation of the skin
  • joint pain
  • increased white blood cell count

These are not all the possible side effects of TARPEYO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

TARPEYO may cause serious side effects, including effects of having too much corticosteroid medicine in your blood (hypercorticism), adrenal suppression, and risk of immunosuppression.

87% of patients in the clinical study completed the 2-year study

Increases in blood pressure were small and resolved to baseline levels by the end of the 9-month treatment period

Blood pressure: Increases in blood pressure were small and resolved to baseline levels by the end of the 9-month treatment period

Weight gain

Weight gain: Increases in body weight were minor and did not exceed 2.2 lb. Patients returned to pretreatment weight within 3 months of ending treatment

hba1c

HbA1c: HbA1c was generally unchanged throughout treatment. Increases in HbA1c observed during treatment generally resolved after the end of treatment

  

Indication

What is TARPEYO?

TARPEYO is a prescription medicine used to reduce the loss of kidney function in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN) who are at risk for their disease getting worse. It is not known if TARPEYO is safe and effective in children.

Important Safety Information

Do not take TARPEYO if you are allergic to budesonide or any of the ingredients in TARPEYO. See the end of the Patient Information for a complete list of ingredients in TARPEYO.

Before taking TARPEYO, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • plan to have surgery
  • have chicken pox or measles or have recently been near anyone with chicken pox or measles
  • have an infection
  • have high blood sugar levels (prediabetes or diabetes)
  • have glaucoma or cataracts
  • have a family history of diabetes or glaucoma
  • have or have had tuberculosis
  • have high blood pressure (hypertension)
  • have decreased bone mineral density (osteoporosis)
  • have stomach ulcers
  • are pregnant or plan to become pregnant. TARPEYO may harm your unborn baby. Talk to your healthcare provider about the possible risk to your unborn baby if you take TARPEYO when you are pregnant
  • are breastfeeding or plan to breastfeed. It is not known if TARPEYO passes into your breast milk or if it will affect your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with TARPEYO

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TARPEYO and other medicines may affect each other causing side effects.

How should I take TARPEYO?

  • Take TARPEYO exactly as your healthcare provider tells you
  • Your healthcare provider will decide how long you should take TARPEYO. Do not stop taking TARPEYO without first talking with your healthcare provider
  • Take your prescribed dose of TARPEYO 1 time each day in the morning, at least 1 hour before a meal
  • Swallow TARPEYO capsules whole. Do not open, chew, crush, or break TARPEYO capsules before swallowing
  • If you miss a dose of TARPEYO, take your prescribed dose at your next scheduled time. Do not take two doses of TARPEYO at the same time
  • If you take too much TARPEYO, call your healthcare provider right away or go to the nearest hospital emergency room

What should I avoid while taking TARPEYO?

Do not eat grapefruit or drink grapefruit juice during your treatment with TARPEYO. Eating grapefruit or drinking grapefruit juice can increase the level of TARPEYO in your blood.

What are the possible side effects of TARPEYO? 
TARPEYO may cause serious side effects, including:

  • Effects of having too much corticosteroid medicine in your blood (hypercorticism): Long-time use of TARPEYO can cause you to have signs and symptoms of too much cortisol, a stress hormone in your blood. Tell your healthcare provider if you have any of the following signs and symptoms of hypercorticism: acne, bruise easily, rounding of your face (moon face), ankle swelling, thicker or more hair on your body and face, a fatty pad or hump between your shoulders (buffalo hump), or pink or purple stretch marks on the skin of your abdomen, thighs, breasts, or arms
  • Adrenal suppression: When TARPEYO is taken for a long period of time (chronic use), adrenal suppression can happen. This is a condition in which the adrenal glands do not make enough steroid hormones. Symptoms of adrenal suppression include tiredness, weakness, nausea and vomiting, and low blood pressure. Tell your healthcare provider if you are under stress or have any symptoms of adrenal suppression during treatment with TARPEYO
  • Risk of immunosuppression: TARPEYO weakens your immune system. Taking medicines that weaken your immune system makes you more likely to get infections. Avoid contact with people who have contagious diseases, such as chicken pox or measles, during treatment with TARPEYO. Tell your healthcare provider right away if you come in contact with anyone who has chicken pox or measles. Consult with your healthcare provider regarding appropriate vaccination scheduling
  • Tell your healthcare provider if you develop any symptoms of infection during treatment with TARPEYO, including fever, feeling tired, chills, aches, pain, and nausea and vomiting

The most common side effects of TARPEYO include:

  • swelling of the lower legs, ankles, and feet
  • high blood pressure
  • muscle spasms
  • acne
  • headache
  • upper respiratory tract infection
  • swelling of the face
  • weight increase
  • indigestion
  • irritation or inflammation of the skin
  • joint pain
  • increased white blood cell count

These are not all the possible side effects of TARPEYO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information.

++ --
  

Indication

What is TARPEYO?

TARPEYO is a prescription medicine used to reduce the loss of kidney function in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN) who are at risk for their disease getting worse. It is not known if TARPEYO is safe and effective in children.

Important Safety Information

Do not take TARPEYO if you are allergic to budesonide or any of the ingredients in TARPEYO. See the end of the Patient Information for a complete list of ingredients in TARPEYO.

Before taking TARPEYO, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • plan to have surgery
  • have chicken pox or measles or have recently been near anyone with chicken pox or measles
  • have an infection
  • have high blood sugar levels (prediabetes or diabetes)
  • have glaucoma or cataracts
  • have a family history of diabetes or glaucoma
  • have or have had tuberculosis
  • have high blood pressure (hypertension)
  • have decreased bone mineral density (osteoporosis)
  • have stomach ulcers
  • are pregnant or plan to become pregnant. TARPEYO may harm your unborn baby. Talk to your healthcare provider about the possible risk to your unborn baby if you take TARPEYO when you are pregnant
  • are breastfeeding or plan to breastfeed. It is not known if TARPEYO passes into your breast milk or if it will affect your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with TARPEYO

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TARPEYO and other medicines may affect each other causing side effects.

How should I take TARPEYO?

  • Take TARPEYO exactly as your healthcare provider tells you
  • Your healthcare provider will decide how long you should take TARPEYO. Do not stop taking TARPEYO without first talking with your healthcare provider
  • Take your prescribed dose of TARPEYO 1 time each day in the morning, at least 1 hour before a meal
  • Swallow TARPEYO capsules whole. Do not open, chew, crush, or break TARPEYO capsules before swallowing
  • If you miss a dose of TARPEYO, take your prescribed dose at your next scheduled time. Do not take two doses of TARPEYO at the same time
  • If you take too much TARPEYO, call your healthcare provider right away or go to the nearest hospital emergency room

What should I avoid while taking TARPEYO?

Do not eat grapefruit or drink grapefruit juice during your treatment with TARPEYO. Eating grapefruit or drinking grapefruit juice can increase the level of TARPEYO in your blood.

What are the possible side effects of TARPEYO? 
TARPEYO may cause serious side effects, including:

  • Effects of having too much corticosteroid medicine in your blood (hypercorticism): Long-time use of TARPEYO can cause you to have signs and symptoms of too much cortisol, a stress hormone in your blood. Tell your healthcare provider if you have any of the following signs and symptoms of hypercorticism: acne, bruise easily, rounding of your face (moon face), ankle swelling, thicker or more hair on your body and face, a fatty pad or hump between your shoulders (buffalo hump), or pink or purple stretch marks on the skin of your abdomen, thighs, breasts, or arms
  • Adrenal suppression: When TARPEYO is taken for a long period of time (chronic use), adrenal suppression can happen. This is a condition in which the adrenal glands do not make enough steroid hormones. Symptoms of adrenal suppression include tiredness, weakness, nausea and vomiting, and low blood pressure. Tell your healthcare provider if you are under stress or have any symptoms of adrenal suppression during treatment with TARPEYO
  • Risk of immunosuppression: TARPEYO weakens your immune system. Taking medicines that weaken your immune system makes you more likely to get infections. Avoid contact with people who have contagious diseases, such as chicken pox or measles, during treatment with TARPEYO. Tell your healthcare provider right away if you come in contact with anyone who has chicken pox or measles. Consult with your healthcare provider regarding appropriate vaccination scheduling
  • Tell your healthcare provider if you develop any symptoms of infection during treatment with TARPEYO, including fever, feeling tired, chills, aches, pain, and nausea and vomiting

The most common side effects of TARPEYO include:

  • swelling of the lower legs, ankles, and feet
  • high blood pressure
  • muscle spasms
  • acne
  • headache
  • upper respiratory tract infection
  • swelling of the face
  • weight increase
  • indigestion
  • irritation or inflammation of the skin
  • joint pain
  • increased white blood cell count

These are not all the possible side effects of TARPEYO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information.

Calliditas Therapeutics Logo
This site is intended only for US residents. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider. TARPEYO is a registered trademark of Calliditas Therapeutics AB, or its affiliates.
© Calliditas Therapeutics AB All rights reserved. 7/24 US-TAR-2400121